BIOAKTIVITAS ANTIMALARIA EKSTRAK METANOL SPONS Petrosia ficiformis ASAL TANJUNG RUM TIDORE KEPULAUAN

Sabir Sumarna, Mahruf Azis, Suwandi S Sangadji, Irsan Nurdin Idrus

Abstract


Malaria adalah masalah kesehatan serius disebabkan parasit Plasmodium falciparum telah resisten (kebal) terhadap obat antimalaria yang ada seperti chloroquin. Obat baru dengan struktur molekul dan mekanisme aksi yang unik sangat diperlukan untuk menggantikan obat-obat yang telah reisten. Uji bioaktivitas antimalaria ekstrak metanol spons P. ficiformis telah dilakukan terhadap parasit Plasmodium falciparum strain 3D7. Ekstrak spons diperoleh dengan metode maserasi menggunakan pelarut metanol dan uji aktivitas antimalarial menggunakan metode in-vitro dengan variasi konsentrasi ekstrak 0,01, 0,1, 1, 10, dan 100 µg/mL. Hasil penelitian menunjukkan bahwa ekstrak metanol spons P. ficiformis sangat efektif menghambat pertumbuhan parasit malaria dengan nilai IC50 = 20,489 µg/mL.

Keywords


Antimalaria, Spons, Petrosia ficiformis, Tidore Kepulauan

References


Ang, K.K.H., Holmes, M.J., Higa, T., Hamann, M.T., Kara, U.A.K., 2000, In vivo antimalarial activity of the .beta.-carboline alkaloid manzamine A. Antimicrob. Agent. Chemother., 44, 1645-1649.

Cafieri, F., Fattorusso, E., Magno, S., Santacroce, C., Sica, D., 1973, Isolation and structure of axisonitrile 1 and axisothiocyanate 1, two unusual sesquiterpenoids from the marine sponge Axinella cannabina. Tetrahedron, 29, 4259-4262.

Clark, B.R., Engene, N., Teasdale, M.E., Rowley, D.C., Matainaho, T., Valeriote, F.A., Gerwick, W.H., 2008. Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. J. Nat. Prod., 71, 1530–1537.

Di Blasio, B., Fattorusso, E., Magno, S., Mayol, L., Pedone, C., Santacroce, C., Sica, D., 1976, Axisonitrile-3, axisothiocyanate-3 and axamide-3. Sesquiterpenes with a novel spiro[4,5]decane skeleton from the sponge Axinella cannabina. Tetrahedron, 32, 473-478.

Fattorusso, C., Campiani, G., Catalanotti, B., Persico, M., Basilico, N., Parapini, S., Taramelli. D., Campagnuolo, C., Fattorusso, E., Romano, A., Taglialatela-Scafati, O., 2006, Endoperoxide Derivatives from Marine Organisms: 1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents. J. Med. Chem., 49, 7088-7094.

Fattorusso, C., Persico, M., Calcinai, B., Cerrano, C., Parapini, S., Taramelli, D., Novellino, E., Romano, A., Scala, F., Fattorusso, E., Taglialatela-Scafati, O., 2010, Manadoperoxides A-D from The Indonesian Sponge Plakortis cfr. Simplex. Further Insights on Structure -Activity Relationships of Simple 1,2-Dioxane Antimalarials, Journal of Natural Product, 73, 1138- 1145.

Fattorusso, E. and Scafati, O. T., 2009, Marine Antimalarials, Marine Drugs, 7, 130-152.

Fattorusso, E., Parapini, S., Campagnuolo, C., Basilico, N., Taglialatela-Scafati, O., Taramelli, D.. 2002, Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex. J. Antimicrob. Chemother., 50, 883-888.

Garson, M. J., 1994, The Biosynthesis of Secondary Metabolits: Why is Important. In: Sponss in Time and Space, pp: 428-429, edited by R.W.M. van Soest, Th. M.G. Van Kempen and J.C Braekman (eds.). Proceeding 4th International Porifera Conggress, Amsterdam/Netherland.

Giyanto, 2012, Ekosistem Pesisir Ternate, Tidore dan Sekitarnya, Propinsi Maluku Utara 2012, CRITC-Pusat Penelitian Oseanografi LIPI, Jakarta.

Kasettrathat, C., Ngamrojanavanich, N., Wiyakrutta, S., Mahidol, C., Ruchirawat, S., Kittakoop, P., 2008. Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01. Phytochemistry, 69, 2621–2626.

Kaur, K., Jain, M., Kaur, T., Jain, R., 2009, Antimalarials from Nature, Bioorganic & Medicinal Chemistry, Elsevier.

McPhail, K.L., Correa, J., Linington, R.G., Gonzalez, J., Ortega-Barria, E., Capson, T.L., Gerwick, W.H., 2007. Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. J. Nat. Prod., 70, 984–988.

Mehbub, M.F., Lei, J., Franco, C., Zhang, W., 2014, Marine Sponge Derived Natural Products between 2001 and 2010: Trends and Opportunities for Discovery of Bioakctives, Marine Drugs, 12, 4539-4577.

Na, M., Meujo, D.A.F., Kevin, D., Hamann, M.T., Anderson, M., Hill, R.T., 2008. A new antimalarial polyether from a marine Streptomyces sp. H668. Tetrahedron Lett. 49, 6282–6285.

Pontius, A., Krick, A., Kehraus, S., Brun, R., Konig, G.M., 2008a. Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp. J. Nat. Prod., 71, 1579–1584.

Rao, K.V., Donia, M.S., Peng, J., Garcia-Palomero, E., Alonso, D., Martinez, A., Medina, M., Franzblau, S.G., Tekwani, B.L., Khan, S.I., Wayhuono, S., Willett, K.L., Hamann, M.T., 2006, Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity against Infectious, Tropical Parasitic, and Alzheimer's Diseases. J. Nat. Prod., 69, 1034-1040.

Sipkema, D., Franssen, M.C.R., Osinga, R., Tramper, J., Wijffels, R.H., 2005, Marine Sponges as pharmacy, Marine Biotechnology, 7, 142-162.

Snow, R.W., Guerra, C.A., Noor, A.M., Myint, H.Y., and Hay, S.I., 2005, The Global Distribution of Clinical Episodes of Plasmodium falciparum Malaria, Letters to Nature, Vol. 434, 214- 2017.

Tasdemir, D., Topaloglu, B., Perozzo, R., Brun, R., O'Neill, R., Carballeira, N.M., Zhang, X., Tonge, P.J., Linden, A., Ruedi, P., 2007. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Bioorg. Med. Chem. 15, 6834–6845.

Xu, M., Andrews, K.T., Birrell, G.W., Tran, T.L., Camp, D., Davis, R.A., Quinn, R.J., 2011, PsammapLysin H, a New antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina, Bioorganic & Medicinal Chemistry Letters, Elsevier.




DOI: http://dx.doi.org/10.33387/tk.v8i2.1352

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TECHNO: Jurnal Penelitian

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