POLA JUMLAH TROMBOSIT PADA ANAK YANG MENDERITA DEMAM DENGUE (DF) DAN DEMAM BERDARAH DENGUE (DHF) DI RSUD Dr H CHASAN BOESOIRIE TERNATE PERIODE JANUARI-NOVEMBER 2019

Marhaeni Hasan

Sari


Dengue is an acute virus infectious disease caused by the dengue virus and transmitted by Aedes
aegypty mosquitoes with high mortality and morbidity in many regions of the world. Thrombocytopenia is one
of the laboratory parameters in diagnosing dengue virus infection that has the possibility to change day by day.
To study the thrombocyte count pattern in dengue fever (DF) and dengue haemorrhagic fever (DHF) in
pediatrics patient. This type of research is a cross sectional analytic study with a retrospective design, using
secondary data from medical records in Pediatrics department of Dr H Chasan Boesoirie distric hospital
during January-November 2019 period. The research sample was aged <15 years, diagnosis of DF and DHF
according to WHO 2011 criteria, the data regarding thrombocyte counts, days of sickness, the patient’s
characteristics and for statistical analysis Mann-whitney test was used. On average, the thrombocyte count in
DF patients starts dropping by the 4th day. It reaches its lowest point on the 5th day and starts going up on 6th
day. In DHF patients, on average, the thrombocyte count drops by the 3rd day, hits lowest point on the 5th, and
goes back up on the 6th day. In DHF patients with shock, the average thrombocyte count on the 3rdday is 50.000
cells/mm3 while the lowest count, on average on the 6th day is 42.000 cells/mm3. This number starts going up on
the 7th day. There is a significant difference in the average thrombocyte count between DF and DHF patients
on the 3rd, 4th, 5th, and 6th day (p<0.05) . As for DHF patients without shock, a significant difference was found
on the 6th day (51.000 cells/mm3 and 81.000 cells/mm3, p=0.047). There is a significant difference in the
average thrombocyte counts between DF and DHF patients. The declining count to <100,000 cells/mm3 on the
3rd day of sickness has to be taken cautiously in order to prevent from making the shock worse.


Teks Lengkap:

DOWNLOAD PDF

Referensi


World Health Organization (WHO). Dengue Guidelines for Diagnosis,Treatment,Prevention and

Control. New Ed. (2009).

World Health Organization (WHO). WHO Report on Global Surveillance of Epidemic-prone

Infectious Diseases. (2000).

Situasi Penyakit Demam Berdarah di Indonesia Tahun 2017. Data dan Informasi Profil Kesehatan

Indonesia Kementrian Kesehatan Republik Indonesia. ISSN 2442-7659 (2018).

Pusat Data dan Informasi Kementrian Kesehatan RI. ISSN 2442-7659 (2016).

Guilarde, A. O. et al. Dengue and Dengue Hemorrhagic Fever among Adults : Clinical Outcomes

Related to Viremia , Serotypes , and Antibody Response. 050, 817–824 (2008).

Dinas Kesehatan Kab/Kota. Data Penderita Demam Berdarah Dengue. (2016).

Dinas Kesehatan Kab/Kota. Data Kasus dan Kematian Demam Berdarah Dengue. (2019).

EMB, L. et al. Circulating human antibodies against dengue NS1 protein: potential of recombinant

D2V-NS1 proteins in diagnostic tests. J. Clin. Virol.32, (2005).

John Hall. Guyton dan Hall Buku Ajar Fisiologi Kedokteran 12th Edition. (2014).

R, K. Y. et al. Pola Jumlah Trombosit Pasien Rawat Inap DBD RSUP Dr . Mohammad Hoesin

Palembang Dengan Hasil Uji Serologi Positif yang Diperiksa di Laboratorium Graha Spesialis RSUP

Dr . Mohammad Hoesin Palembang. 2, 104–110 (2014).

Pusparini. Kadar hematokrit dan trombosit sebagai indikator diagnosis infeksi dengue primer dan

sekunder. Jurnal Kedokteran Trisakti.;23(2): 51-6. (2004)

Suroso, Chrishantoro T. Kombinasi sinergis deteksi infeksi dengue aktif dan prognosis dengue shock

syndrome. Jakarta: PT Pacific Biotekindo Intralab; 2004.h.3-4

Dewi R, Tumbelaka AR, Sjarif DR. Clinical features af dengue hemorrhagic fever and risk factors of

shock event. Pediatr Indones 2006;46:144-8.

Heatubun CE, Umboh A, Mogan AE, Manoppo F. Perbandingan jumlah trombosit pada demam

berdarah dengue tanpa syok dan syok di RSUP Prof.Dr.R.D. Kandou Manado.ejournal.Unsrat 2013;

:863-7.

Sutirta-Yasa, I. W. P., Putra, G. A. E. T. & Rahmawati, A. Trombositopenia pada Demam Berdarah

Dengue. Medicina (B. Aires).43, 114–121 (2012).

Jayashree K, Manasa GC, Pallavi P, Manjunath GV. Evaluation of platelets as Predictive Parameters

in Dengue Fever. Indian J Hematol Blood Transfus 2011;27:127–30.

Shah GS, Islam S, Das BK. Clinical and Laboratory Profile of Dengue Infection in Children.

Kathmandu University Med J. 2006;4:40-43.

Sari.R.C, Kahar H. Puspitasari D. Pola Jumlah Trombosit Pasien Infeksi Virus Dengue yang Dirawat

di SMF Ilmu Kesehatan Anak RSUD Dr. Soetomo Surabaya: Sari Pediatri 2017;19(1):1-6

Mayetti. 2010. Hubungan klinis dan laboratorium sebagai faktor resiko syok pada DBD. Sari Pediatri.

(5):370-72.




DOI: https://doi.org/10.33387/kmj.v2i1.2325

Refbacks

  • Saat ini tidak ada refbacks.


##submission.copyrightStatement##


Journal PoliciesSubmissionsPeople
 Informatio

Fakultas Kedokteran, Universitas Khairun | Jl. Jusuf Abdulrahman Kotak Pos 53 Gambesi, Kota Ternate, Indonesia

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
slot gacor slot gacor hari ini slot gacor 2025 demo slot pg slot gacor slot gacor